I do not remember the first rpg I GMed. It was likely AD&D or Superworld (from Choasium). They would have been one-shots for my little brother. The first game I ran as a campaign was Werewolf: The Apocalypse. Robb was running VtM, so I picked this one up. Some of my fondest campaign memories are from the all but one female group and the one was again, my little brother. He was not always available to play with us. It was after high school for me and we would often start late at night and end early in the morning. He was in high school and very active with tennis at the time.
I would go on to run other campaigns via WtA. Another great one was a four person, six episodes, miniseries of a game with an awesome climatic battle as the pups became full on warriors of Gaia. The entire thing was action-packed fun that I wish could be captured in a bottle and doled out as needed. The players were very into their characters and I was dead on with the NPCs.
I made it to second edition, but not third. I have picked up the nWoD core book, but have not done anything with it. If you are looking for a game with a lot of combat in the modern day, this could be the game for you.
When will you rage?